LATS1 / WARTS Recombinant Rabbit Monoclonal Antibody [PSH07-20]

功能

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene. It has been associated with the Hippo signaling pathway, where it phosphorylates YAP and TAZ to inactivate their function. The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced histone H1 kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

背景文献

1. Xu Y et al. The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer. J Exp Clin Cancer Res. 2023 Jan

2. Qi S et al. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Mol Cell. 2022 May

亚细胞定位

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, spindle, microtubule organizing center, spindle pole body.

UNIPROT

SwissProt: O95835 Human

SwissProt: Q8BYR2 Mouse

别名

h-warts antibody

Large tumor suppressor homolog 1 antibody

LATS large tumor suppressor homolog 1 antibody

LATS1 antibody

LATS1_HUMAN antibody

Serine threonine protein kinase LATS1 antibody

Serine/threonine-protein kinase LATS1 antibody

WARTS antibody

WARTS protein kinase antibody

wts antibody