PI 3 Kinase p110 delta Recombinant Rabbit Monoclonal Antibody [JM83-24]

功能

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene. p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmunity and transplant rejection. Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110α, p110β and p110γ. p110α and p110β interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.

背景文献

1. Matsukawa K et al. Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. J Biol Chem 291:23464-23476 (2016).

2. Guo Z et al. A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization. Microbes Infect 16(3):225-36 (2014).

序列相似性

Belongs to the PI3/PI4-kinase family.

组织特异性

Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.

翻译后修饰

Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.

亚细胞定位

Cytoplasm.

UNIPROT

SwissProt: O00329 Human

SwissProt: O35904 Mouse

SwissProt: D4A5Q1 Rat

别名