TLR7 Recombinant Rabbit Monoclonal Antibody [JA93-11]

功能

The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NFκB signaling pathway, suggesting that they play a role in the immune response.

背景文献

1. Tao Y et al. The role of endogenous IFN- in the regulation of Th17 responses in patients with relapsing-remitting multiple sclerosis. J Immunol 192:5610-7 (2014).

2. Chen GY et al. Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide. Biomaterials 33:6559-69 (2012).

序列相似性

Belongs to the Toll-like receptor family.

组织特异性

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

亚细胞定位

Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle, phagosome.

UNIPROT

SwissProt: Q9NYK1 Human

别名

PRO285 antibody

TLR 7 antibody

Tlr7 antibody

TLR7_HUMAN antibody

Toll like receptor 7 antibody

Toll-like receptor 7 antibody

UNQ248 antibody