PPAR alpha Mouse Monoclonal Antibody

功能

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARα, PPARβ (also designated PPARδ) and PPARγ, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARα is abundant in primary hepatocytes where it regulates the expression of proteins involved in fatty acid metabolism. Interestingly, both the orphan nuclear hormone receptor LXRα and thyroid receptor (TR) have been shown to act as antagonists of PPARα/RXRα binding to PPREs.

背景文献

1. Randriamboavonjy JI et al. Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats. Am J Hypertens 29:873-81 (2016).

2. Li XH et al. Neuroprotective effects of sodium hydrosulfide against -amyloid-induced neurotoxicity. Int J Mol Med 38:1152-60 (2016).

亚细胞定位

Nucleus.

UNIPROT

SwissProt: Q07869 Human

别名