MAVS Rabbit Polyclonal Antibody
Catalog# ER1912-80
MAVS Rabbit Polyclonal Antibody
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WB
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Mouse
概述
产品名称
MAVS Rabbit Polyclonal Antibody
抗体类型
Rabbit Polyclonal Antibody
免疫原
KLH conjugated synthetic peptide derived from human MAVS N terminus 3-100/540
种属反应性
Mouse
验证应用
WB
分子量
56 KDa
阳性对照
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
偶联
unconjugated
产品特性
形态
Liquid
存放说明
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
存储缓冲液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:500-2000
靶点
功能
Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis
背景文献
暂无
亚细胞定位
Mitochondrion outer membrane.
UNIPROT
别名
CARD adapter inducing interferon beta antibody
CARD adaptor inducing IFN beta antibody
Cardif antibody
DKFZp666M015 antibody
FLJ27482 antibody
FLJ41962 antibody
IFN B promoter stimulator 1 antibody
Interferon beta promoter stimulator protein 1 antibody
Ips 1 antibody
IPS-1 antibody
展开图片
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Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti- MAVS (ER1912-80) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 56 kD
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
MAVS Recombinant Rabbit Monoclonal Antibody [PSH0-30]
Application: WB,IHC-P,IF-Cell,IP
Reactivity: Human,Mouse
Conjugate: unconjugated
MAVS Recombinant Rabbit Monoclonal Antibody [PSH01-65]
Application: WB,IHC-P,IF-Cell,IF-Tissue
Reactivity: Human
Conjugate: unconjugated
同靶点 & 同通路的产品
MAVS Recombinant Rabbit Monoclonal Antibody [PSH0-30]
Application: WB,IHC-P,IF-Cell,IP
Reactivity: Human,Mouse
Conjugate: unconjugated
MAVS Recombinant Rabbit Monoclonal Antibody [PSH01-65]
Application: WB,IHC-P,IF-Cell,IF-Tissue
Reactivity: Human
Conjugate: unconjugated
