FUT4 Mouse Monoclonal Antibody [B4-B11]

功能

Fucosyltransferases (FucTs) catalyze the covalent association of fucose to different positional linkages on sugar acceptor molecules. The carbohydrate moieties that are generated are covalently attached to cell surfaces and are necessary to ensure a surface contour that satisfies a variety of physiological roles. CD15, also known as Lewis X or LeX, is a carbohydrate antigen that is generated by FucT-IV (alpha 1,3-fucosyltransferase IV). Commonly found on the surface of leukocytes and some tumor cells, CD15 is a trisaccharide that is synthesized when FucT-IV transfers an α-fucose residue onto the β-GlcNAc moiety of cellular N-acetyllactosamines. CD15 functions as an adhesion molecule capable of calcium-mediated homotypic binding. Cells with high surface expression of CD15, therefore, exhibit strong self-aggregation (based on CD15-CD15 interaction) in the presence of calcium. Additionally, CD15 is thought to be a ligand for Selectins (proteins involved in mediating leukocyte-specific cellular interactions), further supporting its role as a cell-adhesion protein.

背景文献

1. Sabry M et al. Leukemic priming of resting NK cells is killer Ig-like receptor independent but requires CD15-mediated CD2 ligation and natural cytotoxicity receptors. J Immunol 187(12):6227-34 (2011).

2. de Antonellis P et al. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLoS One 6(9):e24584 (2011).

亚细胞定位

Golgi Apparatus, membrane-bound form in trans cisternae of Golgi.

UNIPROT

SwissProt: P22083 Human

别名