SIRT5 Recombinant Rabbit Monoclonal Antibody [JJ084-01]

功能

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

背景文献

1. Tan M., et al. 2014. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 19:605-617.

2. Bian Y., et al. 2014. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics 96:253-262.

序列相似性

Belongs to the sirtuin family. Class III subfamily.

组织特异性

Widely expressed.

亚细胞定位

Mitochondrion matrix, Mitochondrion intermembrane space, Cytoplasm, cytosol, Nucleus.

UNIPROT

SwissProt: Q9NXA8 Human

SwissProt: Q8K2C6 Mouse

别名