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Anti-Sulfadimidine Recombinant Rabbit Monoclonal Antibody [HuaM009-51B]

重组兔单抗 | 货号: HA721132


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价格:RMB   1500
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  • 概述

  • 产品描述 Sulfamethazine is a sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position. It has a role as an antiinfective agent, a carcinogenic agent, a ligand, an antibacterial drug, an antimicrobial agent, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a member of pyrimidines, a sulfonamide and a sulfonamide antibiotic. It derives from a sulfanilamide. Sulfamethazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamethazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA. Sulfamethazine may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns. Sulfamethazine produces thyroid tumors in mice and rats by a non-genotoxic mechanism, which involves inhibition of thyroid peroxidase resulting in alterations in thyroid hormone concn and incr secretion of thyroid stimulating hormone. Consequently, sulfamethazine would be expected not to be carcinogenic to humans exposed to doses that do not alter thyroid hormone homeostasis. Evidence from epidemiological studies and from toxicological studies in experimental animals provide compelling evidence that rodents are substantially more sensitive than humans to the development of thyroid tumors in response to thyroid hormone imbalance. This antibody does not cross-react with Sulfamethoxypyridazine and sulfamethoxazole.
  • 产品名称 Anti-Sulfadimidine Recombinant Rabbit Monoclonal Antibody [HuaM009-51B]
  • 种属反应性 Species independent
  • 验证应用 ELISA
  • 抗体类型 重组兔单抗
  • 免疫原 Sulfadimidine
  • 偶联 Non-conjugated
  • RRID AB_3072256
  • 性能

  • 形态 Liquid
  • 浓度 1mg/ml
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 PBS (pH7.4).
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 其它名称
    • sulfamethazine
    • Sulfadimidine
    • 57-68-1
  • 应用

    ELISA: 1:10,000

  • 背景文献

  • 暂无
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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols