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Anti-GAPDH Recombinant Rabbit Monoclonal Antibody [SA30-01]

重组兔单抗 | 货号: ET1601-4


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价格:RMB   1500
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  • 概述

  • 产品描述 Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
  • 产品名称 Anti-GAPDH Recombinant Rabbit Monoclonal Antibody [SA30-01]
  • 分子量 Predicted band size: 36 kDa
  • 种属反应性 Human,Mouse,Rat,Chicken, Zebrafish
  • 验证应用 WB,IF-Cell,IF-Tissue,IHC-P,FC,IP
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within mouse GAPDH aa 94-333 / 333.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoplasm, Nucleus, Membrane
  • 数据链接 SwissProt: P04406 Human
    SwissProt: P16858 Mouse
    SwissProt: P04797 Rat
  • 其它名称
    • 38 kDa BFA-dependent ADP-ribosylation substrate antibody
    • aging associated gene 9 protein antibody
    • Aging-associated gene 9 protein antibody
  • 应用

    WB: 1:5,000-1:640,000
    IF-Cell: 1:50
    IF-Tissue: 1:50
    IHC-P: 1:50
    FC: 1:50
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. "High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase."Jenkins J.L., Tanner J.J.Acta Crystallogr. D 62:290-301(2006)

    2. "Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase."Ismail S.A., Park H.W.Acta Crystallogr. D 61:1508-1513(2005)
  • Publishing research using Anti-GAPDH Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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