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2023开学季

Anti-FAP Recombinant Rabbit Monoclonal Antibody [JA56-11]

重组兔单抗 | 货号: ET1704-23


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价格:RMB   1500
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  • 概述

  • 产品描述 FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is co-localized with MMP-1and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.
  • 产品名称 Anti-FAP Recombinant Rabbit Monoclonal Antibody [JA56-11]
  • 分子量 88 kDa
  • 种属反应性 Human
  • 验证应用 WB,IHC-P,mIHC
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within Human FAP1 aa 1-160 / 760.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cell membrane. Cell surface.
  • 数据链接 SwissProt: Q12884 Human
  • 其它名称
    • 170 kDa melanoma membrane bound gelatinase antibody
    • 170 kDa melanoma membrane-bound gelatinase antibody
    • DPPIV antibody
  • 应用

    WB: 1:500-1:1,000
    IHC-P: 1:50-1:200
    mIHC: 1:3,000

  • 背景文献

  • 1. Jia, B. et al. 2016. GPR30 Promotes Prostate Stromal Cell Activation via Suppression of ERα Expression and Its Downstream Signaling Pathway. Endocrinology. 157: 3023-35.

    2. Knopf, JD. et al. 2015. The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia. Biochim. Biophys. Acta. 1853: 2515-25.
  • Publishing research using Anti-FAP Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols