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Anti-Di-mehtyl-Histone H3(Lys4) Rabbit Polyclonal Antibody

兔多抗 | 货号: R1110-3


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价格:RMB   1600
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  • 概述

  • 产品描述 The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
  • 产品名称 Anti-Di-mehtyl-Histone H3(Lys4) Rabbit Polyclonal Antibody
  • 分子量 Predicted band size: 15 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,ICC,IHC-P,FC
  • 抗体类型 兔多抗
  • 免疫原 Synthetic peptide of the N terminal residues of Human Di-mehtyl-Histone H3(Lys4).
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Immunogen affinity purified.
  • 亚细胞定位 Nucleus.
  • 数据链接 SwissProt: P68431 Human
    SwissProt: P68433 Mouse
    SwissProt: Q6LED0 Rat
  • 其它名称
    • Histone H3/a
    • Histone H3/b
    • Histone H3/c
  • 应用

    WB:1:1,000
    ICC:1:50-1:200
    IHC-P:1:50-1:200
    FC:1:50-1:100

  • 背景文献

  • 1. Flanagan J.F et al. Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature 438:1181-1185 (2005).

    2. Iberg A.N et al. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem 283:3006-3010 (2008).
  • Publishing research using Anti-Di-mehtyl-Histone H3(Lys4) Rabbit Polyclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    35949313
    Sanguinarine, identified as a natural alkaloid LSD1 inhibitor, suppresses lung cancer cell growth and migration Author: Qin, T. T., Li, Z. H., Li, L. X., Du, K., Yang, J. G., Zhang, Z. Q., Wu, X. X., & Ma, J. L. Published: 2022 Application: WB Species: Human Journal: Iran J Basic Med Sci. IF: 2.632
  • PMID:
    35707047
    Targeting the LSD1-G9a-ER Stress Pathway as a Novel Therapeutic Strategy for Esophageal Squamous Cell Carcinoma Author: Wang, H., Song, Z., Xie, E., Chen, J., Tang, B., Wang, F., & Min, J. Published: 2022 Application: WB,IHC Species: Mouse Journal: Research (Wash D C). IF: NA

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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