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iFluor™ 594 Conjugated Anti-Cytokeratin 19 Recombinant Rabbit Monoclonal Antibody [SA30-06]

重组兔单抗 | 货号: HA720115F


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价格:RMB   3280
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  • 概述

  • 产品描述 Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells and have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. For example, many types of cancer cells express Cytokeratin 19 (CK19), an epithelial cytoskeletal protein within the suprabasal squamous epithelium. Cytokeratin 19 is a specific marker of moderate to severe dysplasia and carcinoma in situ in oral cavity squamous epithelium, and measurement of Cytokeratin 19 may be a useful marker in diagnosing hepatoma. Cytokeratin 19 fragment levels in serum have been documented as a marker for lung cancer. Clinical investigations have suggested that serum CYFRA 21-1, a fragment of Cytokeratin 19, may be among the most useful tumor markers.
  • 产品名称 iFluor™ 594 Conjugated Anti-Cytokeratin 19 Recombinant Rabbit Monoclonal Antibody [SA30-06]
  • 分子量 Predicted band size: 44 kDa
  • 种属反应性 Human,Mouse
  • 验证应用 IF-Cell,IF-Tissue,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human Cytokeratin 19 aa 348-400.
  • 偶联 iFluor™ 594
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoskeleton.
  • 数据链接 SwissProt: P08727 Human
  • 其它名称
    • 40 kDa keratin intermediate filament antibody
    • CK 19 antibody
    • CK-19 antibody
  • 应用

    IF-Cell: 1:50
    IF-Tissue: 1:100
    FC: 1ug/mL

  • 背景文献

  • 1. Guye P. et. al. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat Commun 7:10243 (2016).

    2. Cui M. et. al. PTEN is a potent suppressor of small cell lung cancer. Mol Cancer Res 12:654-9 (2014).
  • Publishing research using iFluor™ 594 Conjugated Anti-Cytokeratin 19 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols