CRP Mouse Monoclonal Antibody [E8-G1]
Catalog# EM1709-89
CRP Mouse Monoclonal Antibody [E8-G1]
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WB
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IHC-P
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FC
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Human
概述
产品名称
CRP Mouse Monoclonal Antibody [E8-G1]
抗体类型
Mouse Monoclonal Antibody
免疫原
Recombinant protein
种属反应性
Human
验证应用
WB, IHC-P, FC
分子量
25 kDa
阳性对照
Human CRP recombinant protein, human liver cancer tissue, MCF-7.
偶联
unconjugated
克隆号
E8-G1
产品特性
形态
Liquid
浓度
2ug/ul
存放说明
4℃; -20℃ for long term storage.
存储缓冲液
Purified antibody in PBS with 0.05% sodium azide.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
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WB
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1:500-1:1,000
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IHC-P
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1:100-1:500
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FC
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1:100-1:200
靶点
功能
C Reactive Protein(CRP) is produced by liver epithelial cells and is characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Stat3 is involved in mouse CRP gene expression. CRP bind to Fc g R and opsonize particles for phagocytosis by human polymorphonuclear leukocytes. Opsonization of zymosan by CRP is mediated through Fc g RI, while Fc g RII and Fc g RIII are receptors for SAP. Therefore, CRP and SAP play critical roles in the host defense system.
背景文献
暂无
亚细胞定位
Secreted.
UNIPROT
别名
Pentraxin 1, short antibody
C reactive protein antibody
C reactive protein pentraxin related antibody
C-reactive protein(1-205) antibody
CRP antibody
CRP_HUMAN antibody
MGC88244 antibody
Pentraxin 1 antibody
PTX 1 antibody
PTX1 antibody
图片
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Western blot analysis of CRP on human CRP recombinant protein using anti-CRP antibody at 1/1,000 dilution.
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Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-CRP antibody. Counter stained with hematoxylin.
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Flow cytometric analysis of MCF-7 cells with CRP antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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