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2023开学季

Anti-Actin Recombinant Rabbit Monoclonal Antibody [JJ09-29]

重组兔单抗 | 货号: ET1701-80


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价格:RMB   1500
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  • 概述

  • 产品描述 All eukaryotic cells express Actin, which often constitutes as much as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one Actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of Actin are present in mammalian tissues and fall into three classes. α-Actin expression is limited to various types of muscle, whereas β-Actin and γ-Actin are the principle constituents of filaments in other tissues. Members of the small GTPase family regulate the organization of the Actin cytoskeleton. Rho controls the assembly of Actin stress fibers and focal adhesion. Rac regulates Actin filament accumulation at the plasma membrane. Cdc42 stimulates formation of filopodia.
  • 产品名称 Anti-Actin Recombinant Rabbit Monoclonal Antibody [JJ09-29]
  • 分子量 Predicted band size: 42 kDa
  • 种属反应性 Human,Mouse,Rat,Zebrafish
  • 验证应用 WB,IF-Cell,IF-Tissue,IHC-P,IP
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human Actin aa 45-80 / 377.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoplasm, Cytoskeleton.
  • 数据链接 SwissProt: P68133 Human
    SwissProt: P68134 Mouse
    SwissProt: P68136 Rat
    Entrez Gene: 407658 Zebrafish
  • 其它名称
    • a actin antibody
    • ACTA antibody
    • ACTA1 antibody
  • 应用

    WB: 1:5,000
    IF-Cell: 1:100-1:500
    IF-Tissue: 1:100-1:500
    IHC-P: 1:50-1:200
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Moilanen AM et al. WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function. PLoS One 10:e0124907 (2015).

    2. Rafatian N et al. Cardiac macrophages and apoptosis after myocardial infarction: effects of central MR blockade. Am J Physiol Regul Integr Comp Physiol 307:R879-87 (2014).
  • Publishing research using Anti-Actin Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    37275875
    Heart failure-related genes associated with oxidative stress and the immune landscape in lung cancer Author: Duan, R., Ye, K., Li, Y., Sun, Y., Zhu, J., & Ren, J. Published: 2023 Application: WB Species: Human Journal: Front Immunol IF: 8.786
  • PMID:
    36018180
    DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish Author: Shao, G. J., Wang, X. L., Wei, M. L., Ren, D. L., & Hu, B. Published: 2023 Application: WB Species: Zebrafish Journal: Neural Regen Res. IF: 6.058
  • PMID:
    36091397
    Iron supplementation inhibits hypoxia-induced mitochondrial damage and protects zebrafish liver cells from death Author: Hu, R., Li, G., Xu, Q., & Chen, L. Published: 2022 Application: WB Species: Zebrafish Journal: Front Physiol. IF: 4.755
  • PMID:
    35800772
    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination Author: Jiang, J., Li, Y., Sun, Z., Gong, L., Li, X., Shi, F., Yao, J., Meng, Y., Meng, X., Zhang, Q., Wang, Y., Su, X., & Diao, H. Published: 2022 Application: WB Journal: iScience IF: 5.458
  • PMID:
    33760102
    Testis-expressed protein 33 is not essential for spermiogenesis and fertility in mice. Molecular medicine reports, 23(5), 317. Author: Xia, M., Xia, J., Niu, C., Zhong, Y., Ge, T., Ding, Y., & Zheng, Y. Published: 2021 Application: WB Species: Mouse Journal: Mol Med Rep
  • PMID:
    33732417
    Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin. Journal of extracellular vesicles, 10(5), e12078. Author: Zhang, Y., Li, Y., Liu, P., Gong, D., Zhou, H., Li, W., Zhang, H., Zheng, W., Xu, J., Cheng, H., Zhang, X., & Ke, Y. Published: 2021 Application: WB Species: Mouse Journal: J Extracell Vesicles
  • PMID:
    34183370
    Neddylation Alleviates Methicillin-Resistant Staphylococcus aureus Infection by Inducing Macrophage Reactive Oxygen Species Production. Journal of immunology (Baltimore, Md. : 1950), 207(1), 296–307. Advance online publication. Author: Xiu, H., Peng, Y., Huang, X., Gong, J., Yang, J., Cai, J., Zhang, K., Cui, W., Shen, Y., Wang, J., Zhang, S., Cai, Z., & Zhang, G. Published: 2021 Application: WB Species: Mouse Journal: J Immunol IF: 5.422
  • PMID:
    34129943
    Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Molecular & cellular proteomics : MCP, 100115. Advance online publication. Author: Gong, Y., Liu, Y., Wang, T., Li, Z., Gao, L., Chen, H., Shu, Y., Li, Y., Xu, H., Zhou, Z., & Dai, L. Published: 2021 Application: WB Species: Human
  • PMID:
    34541414
    Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells Author: Liu, Q., Luo, Y., Zhao, Y., Xiang, P., Zhu, J., Jing, W., Jin, W., Chen, M., Tang, R., & Yu, H. Published: 2021 Application: WB Species: Human Journal: Bioact Mater IF: 14.593
  • PMID:
    34622921
    Proprotein Convertase Furina Is Required for Heart Development in Zebrafish Author: Zhou, Q., Lei, L., Zhang, H., Chiu, S. C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., & Xiong, J. W. Published: 2021 Species: Zebrafish Journal: J Cell Sci IF: 5.281
  • PMID:
    33304378
    A Novel Nonsense GLI3 Variant Is Associated With Polydactyly and Syndactyly in a Family by Blocking the Sonic Hedgehog Signaling Pathway. Frontiers in genetics, 11, 542004. Author: Yunlan Xu;Hong Jiang;Xiaoqing Zhang Published: 2020 Application: WB Species: human Journal: Front Genet. IF: 3.789
  • PMID:
    33184290
    DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity. Cell death & disease, 11(11), 976. Author: Yongchao Zhao Published: 2020 Application: WB Species: human Journal: Cell Death & Disease IF: 6.304
  • PMID:
    31637003
    The proatherosclerotic function of indoleamine 2,3- dioxygenase 1 in the developmental stage of atherosclerosis Author: Yigang Li,Qing Yang Published: 2019 Application: WB Species: human Journal: Signal Transduction and Targeted Therapy IF: None
  • PMID:
    31611604
    Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells Author: Qian Chu,Xia Zhao,Qiuhong Duan,Feng Zhu Published: 2019 Application: WB Species: human Journal: Cell Death Dis. IF: 5.959
  • PMID:
    29618597
    Regulation of Vascular Calcification by Growth Hormone–Releasing Hormone and Its Agonists Author: Hong Yu Published: 2018 Application: WB Species: Vascular SMCs Journal: Circ Res IF: 15.211

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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