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Anti-ACE2 Recombinant Rabbit Monoclonal Antibody [SN0754]

重组兔单抗 | 货号: ET1611-58


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价格:RMB   2500
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  • 概述

  • 产品描述 Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.
  • 产品名称 Anti-ACE2 Recombinant Rabbit Monoclonal Antibody [SN0754]
  • 分子量 Predicted band size: 92 kDa
  • 种属反应性 Human,Mouse,Hamster, Rat
  • 验证应用 WB,ICC,IHC-P,IP
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human ACE2 aa 181-230 / 805.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cell membrane, Cell projection, Cytoplasm, Membrane, Secreted.
  • 数据链接 SwissProt: Q9BYF1 Human
    SwissProt: Q8R0I0 Mouse
    SwissProt: Q5EGZ1 Rat
    SwissProt: A0A1U7QTA1 Hamster
  • 其它名称
    • ACE 2 antibody
    • ACE related carboxypeptidase antibody
    • ACE-related carboxypeptidase antibody
  • 应用

    WB: 1:1,000-1:5,000
    ICC: 1:100-1:500
    IHC-P: 1:50-1:200
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Thatcher SE et al. Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II-Induced Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol 34:2617-23 (2014).

    2. Honorato-Sampaio K et al. Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle. Exp Physiol 97:642-50 (2012).
  • Publishing research using Anti-ACE2 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    33930369
    CIHH protects the heart against left ventricular remodelling and myocardial fibrosis by balancing the renin-angiotensin system in SHR. Life sciences, 278, 119540. Author: Yu, B., Chen, H., Guo, X. Q., Hua, H., Guan, Y., Cui, F., Tian, Y. M., Zhang, H. X., Zhang, X. J., Zhang, Y., & Ma, H. J. Published: 2021 Species: Rat Journal: Life Sciences IF: 3.647
  • PMID:
    33841179
    Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats. Frontiers in physiology, 12, 639454. Author: Chen, H., Yu, B., Guo, X., Hua, H., Cui, F., Guan, Y., Tian, Y., Zhang, X., Zhang, Y., & Ma, H. Published: 2021 Application: WB Species: Rat Journal: Frontiers in Physiology IF: 4.134
  • PMID:
    32485164
    A Mouse Model of SARS-CoV-2 Infection and Pathogenesis Author: Chang-Fa Fan;Yu-Sen Zhou;Cheng-Feng Qin;You-Chun Wang Published: 2020 Application: WB Species: mouse Journal: Cell Host Microbe. IF: 15.753
  • PMCID:
    PMC7717373
    Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. National Science Review, nwaa285. Author: Liu, F. L., Wu, K., Sun, J., Duan, Z., Quan, X., Kuang, J., Chu, S., Pang, W., Gao, H., Xu, L., Li, Y. C., Zhang, H. L., Wang, X. H., Luo, R. H., Feng, X. L., Schöler, H. R., Chen, X., Pei, D., Wu, G., Zheng, Y. T., … Chen, J. Published: 2020 Application: WB Species: Mouse Journal: National Science Review IF: 16.693
  • PMID:
    31102910
    Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway Author: Tao Guoa,Fengjie Huang Published: 2019 Application: WB Species: human Journal: Biomedicine & Pharmacotherapy IF: 3.457
  • PMID:
    29990483
    Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis Author: Fengjie Huang Published: 2018 Application: WB Species: mouse Journal: Life Sciences IF: 3.234

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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