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Anti-Cyclin A2 Recombinant Rabbit Monoclonal Antibody [SD2052]

重组兔单抗 | 货号: ET1612-26


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价格:RMB   1500
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  • 概述

  • 产品描述 The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin- dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.
  • 产品名称 Anti-Cyclin A2 Recombinant Rabbit Monoclonal Antibody [SD2052]
  • 分子量 49 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,ICC/IF,IHC-P
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within mouse Cyclin A2 aa 1-240 / 422.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Nucleus, Cytoplasm.
  • 数据链接 SwissProt: P20248 Human
    SwissProt: P51943 Mouse
    Unigene: 13094 Rat
  • 其它名称
    • CCN1 antibody
    • CCNA antibody
    • Ccna2 antibody
  • 应用

    WB: 1:500-1:2,000
    ICC/IF: 1:100-1:500
    IHC-P: 1:50-1:200

  • 背景文献

  • 1. Suwei D et al. NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin. J Hematol Oncol 8:120 (2015).

    2. Sharon E et al. Human herpesvirus 6 (HHV-6) alters E2F1/Rb pathways and utilizes the E2F1 transcription factor to express viral genes. Proc Natl Acad Sci U S A 111:451-6 (2014).
  • Publishing research using Anti-Cyclin A2 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    33848642
    Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cellular and molecular gastroenterology and hepatology, S2352-345X(21)00072-2. Advance online publication. Author: Cao, X., Shu, Y., Chen, Y., Xu, Q., Guo, G., Wu, Z., Shao, M., Zhou, Y., Chen, M., Gong, Y., Li, C., Shi, Y., & Bu, H. Published: 2021 Application: WB Species: Mouse Journal: Cellular and Molecular Gastroenterology and Hepatology IF: 7.076
  • PMID:
    31981975
    Canagliflozin impairs blood reperfusion of ischaemic lower limb partially by inhibiting the retention and paracrine function of bone marrow derived mesenchymal stem cells Author: Zhengzheng Li;Zhiting Wang Published: 2020 Application: WB Species: mouse Journal: EBioMedicine. IF: 6.68
  • PMID:
    33087072
    Cell type-specific genotoxicity in estrogenexposed ovarian and fallopian epithelium Author: Liandi Guo;Jie Chen; Cong Liu Published: 2020 Application: IF Species: human Journal: BMC Cancer IF: 3.15

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols