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Anti-Caspase-9 Recombinant Rabbit Monoclonal Antibody [SC65-05]

重组兔单抗 | 货号: ET1610-95


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价格:RMB   1500
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  • 概述

  • 产品描述 Caspase-9 belongs to a family of caspases, cysteine-aspartic proteases involved in apoptosis and cytokine signalling. Apoptotic signals cause the release of cytochrome c from mitochondria and activation of apaf-1 (apoptosome), which then cleaves the pro-enzyme of caspase-9 into the active dimer form. Regulation of this enzyme occurs through phosphorylation by an allosteric inhibitor, inhibiting dimerization and inducing a conformational change. Correct caspase-9 function is required for apoptosis, leading to the normal development of the central nervous system. Caspase-9 has multiple additional cellular functions that are independent of its role in apoptosis. Nonapoptotic roles of caspase-9 include regulation of necroptosis, cellular differentiation, innate immune response, sensory neuron maturation, mitochondrial homeostasis, corticospinal circuit organization, and ischemic vascular injury.
  • 产品名称 Anti-Caspase-9 Recombinant Rabbit Monoclonal Antibody [SC65-05]
  • 分子量 Predicted band size: 46/30/17/37 kDa
  • 种属反应性 Human,Mouse
  • 验证应用 WB,IP
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within Human Caspase-9 aa 95-335 / 416.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Apoptosome, cytosol, Mitochondrion, nucleus, cytoplasm, protein-containing complex.
  • 数据链接 SwissProt: P55211 Human
    SwissProt: Q8C3Q9 Mouse
  • 其它名称
    • Caspase9
    • APAF-3 antibody
    • APAF3 antibody
  • 应用

    WB: 1:500-1:2,000
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Arango-Gonzalez B et al. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One 9:e112142 (2014).

    2. Schattenberg JM et al. Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP. Am J Physiol Gastrointest Liver Physiol 303:G498-506 (2012).
  • Publishing research using Anti-Caspase-9 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols