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Anti-Hsp90 beta Recombinant Rabbit Monoclonal Antibody [SY46-01]

重组兔单抗 | 货号: ET1605-56


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价格:RMB   1500
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  • 概述

  • 产品描述 The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.
  • 产品名称 Anti-Hsp90 beta Recombinant Rabbit Monoclonal Antibody [SY46-01]
  • 分子量 83 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,ICC/IF,IHC-P,IP,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within Human Hsp90 beta aa 485-724 / 724.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoplasm, Melanosome,Nucleus,Secreted,Cell membrane,Dynein axonemal particle .
  • 数据链接 SwissProt: P08238 Human
    SwissProt: P11499 Mouse
    SwissProt: P34058 Rat
  • 其它名称
    • 90 kda heat shock protein beta HSP90 beta antibody
    • D6S182 antibody
    • FLJ26984 antibody
  • 应用

    WB: 1:1,000-1:10,000
    ICC/IF: 1:100-1:500
    IHC-P: 1:50-1:200
    FC: 1:50-1:100
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Carpp LN et al. Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Mol Cell Proteomics 13:2836-54 (2014).

    2. El-Kasaby A et al. A cytosolic relay of heat shock proteins HSP70-1A and HSP90 monitors the folding trajectory of the serotonin transporter. J Biol Chem 289:28987-9000 (2014).
  • Publishing research using Anti-Hsp90 beta Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols