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Anti-Active Caspase-3 Recombinant Rabbit Monoclonal Antibody [SR01-02]

重组兔单抗 | 货号: ET1602-47


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  • 概述

  • 产品描述 Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.
  • 产品名称 Anti-Active Caspase-3 Recombinant Rabbit Monoclonal Antibody [SR01-02]
  • 分子量 Predicted band size: 17 kDa
  • 种属反应性 Human, Pig
  • 验证应用 WB,ICC/IF,IHC-P
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human Caspase-3 aa 28-67 / 277.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoplasm
  • 数据链接 SwissProt: P42574 Human
  • 其它名称
    • Caspase3
    • A830040C14Rik antibody
    • Apopain antibody
  • 应用

    WB: 1:1,000-1:2,000
    ICC/IF: 1:50-1:200
    IHC-P: 1:50-1:200

  • 背景文献

  • 1. Xu TX et al. Hypoxia responsive miR-210 promotes cell survival and autophagy of endometriotic cells in hypoxia. Eur Rev Med Pharmacol Sci 20:399-406 (2016).

    2. Huang X et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep 13:613-22 (2016).
  • Publishing research using Anti-Active Caspase-3 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    35506256
    Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota Author: Wang, C., Wei, S., Liu, B., Wang, F., Lu, Z., Jin, M., & Wang, Y. Published: 2022 Application: WB Species: Pig Journal: Gut Microbes IF: 10.245
  • PMID:
    35957979
    Vitamin D Receptor Genetic Polymorphisms Associate With a Decreased Susceptibility to Extremity Osteomyelitis Partly by Inhibiting Macrophage Apoptosis Through Inhibition of Excessive ROS Production via VDR-Bmi1 Signaling Author: Zhao, X. Q., Wan, H. Y., He, S. Y., Qin, H. J., Yu, B., & Jiang, N. Published: 2022 Application: WB Species: S.aureus Journal: Front Physiol. IF: 4.755
  • PMID:
    36180828
    miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation Author: Li, H., Song, D., Liu, Q., Li, L., Sun, X., Guo, J., Li, D., & Li, P. Published: 2022 Application: WB Species: Mouse Journal: Mol Med. IF: 6.376
  • PMID:
    35538475
    N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma Author: Chen, Y., Lu, Z., Qi, C., Yu, C., Li, Y., Huan, W., Wang, R., Luo, W., Shen, D., Ding, L., Ren, L., Xie, H., Xue, D., Wang, M., Ni, K., Xia, L., Qian, J., & Li, G. Published: 2022 Application: WB Species: Human Journal: Mol Cancer. IF: 41.444
  • PMID:
    35842652
    Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth Author: Hu, J., Cao, J., Jin, R., Zhang, B., Topatana, W., Juengpanich, S., Li, S., Chen, T., Lu, Z., Cai, X., & Chen, M. Published: 2022 Application: WB Species: Human Journal: Cell Commun Signal . IF: 7.525
  • PMID:
    33740524
    Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 138, 111506. Author: Zhang, G., Dai, S., Chen, Y., Wang, H., Chen, T., Shu, Q., Chen, S., Shou, L., & Cai, X. Published: 2021 Application: WB Species: Mouse,Human Journal: Biomed Pharmacother IF: 4.545
  • PMID:
    31322175
    Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β-catenin signaling pathway Author: Dr Xia Liu,Professor Jianchao Wang Published: 2019 Application: WB Species: multiple myeloma cell Journal: MOLECULAR MEDICINE REPORTS IF: 1.851
  • PMID:
    31345225
    SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways. Author: Ziwei Liang Published: 2019 Application: WB Species: glioma cells Journal: Cell Communication and Signaling IF: 5.111

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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