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Anti-Hsp70 Recombinant Rabbit Monoclonal Antibody [SA0379]

重组兔单抗 | 货号: ET1601-11


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价格:RMB   1500
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  • 概述

  • 产品描述 The 70 kilodalton heat shock proteins (Hsp70s) are a family of conserved ubiquitously expressedheat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. When not interacting with a substrate peptide, Hsp70 is usually in an ATP bound state. Hsp70 by itself is characterized by a very weak ATPase activity, such that spontaneous hydrolysis will not occur for many minutes. As newly synthesized proteins emerge from the ribosomes, the substrate binding domain of Hsp70 recognizes sequences of hydrophobic amino acid residues, and interacts with them. This spontaneous interaction is reversible, and in the ATP bound state Hsp70 may relatively freely bind and release peptides. However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis.
  • 产品名称 Anti-Hsp70 Recombinant Rabbit Monoclonal Antibody [SA0379]
  • 分子量 Predicted band size: 70 kDa
  • 种属反应性 Human,Mouse, Rat
  • 验证应用 WB,ICC/IF,IHC-P,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Recombinant protein within Human Hsp70 aa 403-641 / 641.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cytoplasm
  • 数据链接 SwissProt: P0DMV9 Human
    SwissProt: P0DMV8 Human
    SwissProt: P17879 Mouse
    SwissProt: Q61696 Mouse
    SwissProt: Q07439 Rat
  • 其它名称
    • DnaK type molecular chaperone HSP70 1 antibody
    • Epididymis secretory protein Li 103 antibody
    • FLJ54303 antibody
  • 应用

    WB: 1:500
    ICC/IF: 1:50
    IHC-P: 1:50-1:500
    FC: 1:50

  • 背景文献

  • 1. "The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family." Haag Breese E., Uversky V.N., Georgiadis M.M., Harrington M.A.DNA Cell Biol. 25:704-714(2006)

    2. "Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha." Hwang C.Y., Holl J., Rajan D., Lee Y., Kim S., Um M., Kwon K.S., Song B. J. Biol. Chem. 285:7827-7837(2010)
  • Publishing research using Anti-Hsp70 Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    34268419
    The HSP70 gene predicts prognosis and response to chemotherapy in epithelial ovarian cancer. Annals of translational medicine, 9(9), 806. Author: Li, X. F., Hua, T., Li, Y., Tian, Y. J., Huo, Y., & Kang, S. Published: 2021 Application: IHC Species: Human Journal: Ann Transl Med IF: 3.932
  • PMID:
    31507456
    Cellular Evidence and Source of Exosomes in the Biliary System of the Chinese Soft-Shelled Turtle,Pelodiscus sinensis Author: Ping Yang Published: 2019 Application: WB,IHC Species: Pelodiscus sinensis Journal: Front Physiol. IF: 3.201
  • PMID:
    30169545
    Critical role for a promoter discriminator in RpoS control of virulence in Edwardsiella piscicida Author: Xiangshan Zhou Published: 2018 Application: immunoblot Species: Edwardsiella piscicida Journal: PLoS Pathog IF: 6.608

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols