• 概述

• 产品描述 The Fas-associated death domain-containing protein (FADD) was initially identified as an adaptor required for cell death signal transduction initiated by Fas. FADD contains two protein-protein interaction structures: the death domain (DD) at the carboxy terminus and the death effector domain (DED) at the amino terminus. FADD is involved in signaling induced by other DRs such as TNFR-I, TRAIL receptors (or DR4/5), and DR3. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases.
• 产品名称 Anti-FADD antibody
• 分子量 27 kDa
• 种属反应性 Mouse
• 验证应用 WB, FC
• 抗体类型 兔多抗
• 免疫原 Synthetic peptide within N-terminal Mouse FADD.
• 偶联 Non-conjugated

• 性能

• 形态 Liquid
• 浓度 1 mg/mL.
• 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型 IgG
• 纯化方式 Immunogen affinity purified.
• 亚细胞定位 Cell cytosol
• 数据链接 Q61160
  
• 其它名称
  • FADD antibody
  • FADD protein antibody
  • FADD_HUMAN antibody
  • Fas (TNFRSF6) associated via death domain antibody
  • Fas associated via death domain antibody
  • Fas associating death domain containing protein antibody
  • Fas associating protein antibody
  • Fas associating protein with death domain antibody
  • Fas TNFRSF6 associated via death domain antibody
  • FAS-associated death domain protein antibody
  • FAS-associating death domain-containing protein antibody
  • GIG 3 antibody
  • GIG3 antibody
  • Growth inhibiting gene 3 protein antibody
  • Growth-inhibiting gene 3 protein antibody
  • H sapiens mRNA for mediator of receptor induced toxicity antibody
  • Mediator of receptor induced toxicity antibody
  • MGC8528 antibody
  • MORT 1 antibody
  • MORT1 antibody
  • Protein FADD antibody
  more

• 应用

  WB: 1:2,000

• 

  Fig1: Western blot analysis on mouse heart lysates using anti-FADD polyclonal antibody

• 背景文献

• 1. Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G. Hayashizaki Y.;"The transcriptional landscape of the mammalian genome.";Science 309:1559-1563(2005).
  
  2. Zhang J., Winoto A.;"A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis.";Mol. Cell. Biol. 16:2756-2763(1996).

• Publishing research using Anti-FADD antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.