The Fas-associated death domain-containing protein (FADD) was initially identified as an adaptor required for cell death signal transduction initiated by Fas. FADD contains two protein-protein interaction structures: the death domain (DD) at the carboxy terminus and the death effector domain (DED) at the amino terminus. FADD is involved in signaling induced by other DRs such as TNFR-I, TRAIL receptors (or DR4/5), and DR3. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases.
Synthetic peptide within N-terminal Mouse FADD.
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified.
- FADD antibody
- FADD protein antibody
- FADD_HUMAN antibody
- Fas (TNFRSF6) associated via death domain antibody
- Fas associated via death domain antibody
- Fas associating death domain containing protein antibody
- Fas associating protein antibody
- Fas associating protein with death domain antibody
- Fas TNFRSF6 associated via death domain antibody
- FAS-associated death domain protein antibody
- FAS-associating death domain-containing protein antibody
- GIG 3 antibody
- GIG3 antibody
- Growth inhibiting gene 3 protein antibody
- Growth-inhibiting gene 3 protein antibody
- H sapiens mRNA for mediator of receptor induced toxicity antibody
- Mediator of receptor induced toxicity antibody
- MGC8528 antibody
- MORT 1 antibody
- MORT1 antibody
- Protein FADD antibody
Fig1: Western blot analysis on mouse heart lysates using anti-FADD polyclonal antibody
1. Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G. Hayashizaki Y.;"The transcriptional landscape of the mammalian genome.";Science 309:1559-1563(2005).
2. Zhang J., Winoto A.;"A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis.";Mol. Cell. Biol. 16:2756-2763(1996).
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