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Anti-FH Rabbit Polyclonal Antibody

兔多抗 | 货号: ER1901-10


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  • 概述

  • 产品描述 The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
  • 产品名称 Anti-FH Rabbit Polyclonal Antibody
  • 分子量 Predicted band size: 54 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,ICC,IHC-P,FC
  • 抗体类型 兔多抗
  • 免疫原 Recombinant protein within human Fumarase aa 83-267.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Immunogen affinity purified.
  • 亚细胞定位 Mitochondrion, cytosol, nucleus, chromosome.
  • 数据链接 SwissProt: P07954 Human
    SwissProt: P97807 Mouse
    SwissProt: P14408 Rat
  • 其它名称
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
  • 应用

    WB:1:500-1:2,000
    ICC:1:50-1:100
    IHC-P:1:50-1:200
    FC:1:50-1:100

  • 背景文献

  • 1. Ajalla Aleixo M.A. et. al. Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase. FEBS J. 0:0-0(2019).

    2. Jiang Y. et. al. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat. Cell Biol. 17:1158-1168(2015)
  • Publishing research using Anti-FH Rabbit Polyclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols