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Anti-PARP Recombinant Rabbit Monoclonal Antibody [SU03-68]

重组兔单抗 | 货号: ET1608-56


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价格:RMB   1500
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  • 概述

  • 产品描述 The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase (PARG). PARP enzymes are essential in a number of cellular functions, including expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response to TNF.
  • 产品名称 Anti-PARP Recombinant Rabbit Monoclonal Antibody [SU03-68]
  • 分子量 Predicted band size: 113 kDa
  • 种属反应性 Human,Mouse, Rat
  • 验证应用 WB,ICC/IF,IHC-P,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within N-terminal human PARP.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Nucleus, nucleolus, chromosome.
  • 数据链接 SwissProt: P09874 Human
    SwissProt: P11103 Mouse
    SwissProt: P27008 Rat
  • 其它名称
    • ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody
    • ADP ribosyltransferase diphtheria toxin like 1 antibody
    • ADP ribosyltransferase NAD(+) antibody
  • 应用

    WB: 1:1,000
    ICC/IF: 1:50-1:200
    IHC-P: 1:500
    FC: 1:50-1:100

  • 背景文献

  • 1. Cao C et al. The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of -catenin in HCC cells. Gastroenterology 148:415-26.e18 (2015).

    2. Gao S et al. Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway. Mol Vis 20:1374-87 (2014).
  • Publishing research using Anti-PARP Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    36198708
    BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency Author: Wang, F., Liu, Y., Ni, F., Jin, J., Wu, Y., Huang, Y., Ye, X., Shen, X., Ying, Y., Chen, J., Chen, R., Zhang, Y., Sun, X., Wang, S., Xu, X., Chen, C., Guo, J., & Zhang, D. Published: 2022 Application: WB Species: Mouse Journal: Nat Commun. IF: 17.694
  • PMID:
    35538475
    N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma Author: Chen, Y., Lu, Z., Qi, C., Yu, C., Li, Y., Huan, W., Wang, R., Luo, W., Shen, D., Ding, L., Ren, L., Xie, H., Xue, D., Wang, M., Ni, K., Xia, L., Qian, J., & Li, G. Published: 2022 Application: WB Species: Human Journal: Mol Cancer. IF: 41.444
  • PMID:
    35842652
    Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth Author: Hu, J., Cao, J., Jin, R., Zhang, B., Topatana, W., Juengpanich, S., Li, S., Chen, T., Lu, Z., Cai, X., & Chen, M. Published: 2022 Application: WB Species: Human Journal: Cell Commun Signal . IF: 7.525
  • PMID:
    33609560
    Fangchinoline exerts anticancer effects on colorectal cancer by inducing autophagy via regulation AMPK/mTOR/ULK1 pathway. Biochemical pharmacology, 186, 114475. Author: Xiang, X., Tian, Y., Hu, J., Xiong, R., Bautista, M., Deng, L., Yue, Q., Li, Y., Kuang, W., Li, J., Liu, K., Yu, C., & Feng, G. Published: 2021 Application: WB Species: Human Journal: Biochem Pharmacol IF: 4.96
  • PMID:
    32597573
    Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling Author: Chao Shen Published: 2020 Application: WB,IHC Species: human Journal: Cell Prolif. IF: 5.753
  • PMID:
    31322175
    Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β-catenin signaling pathway Author: Dr Xia Liu,Professor Jianchao Wang Published: 2019 Application: WB Species: multiple myeloma cell Journal: MOLECULAR MEDICINE REPORTS IF: 1.851

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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