ACVR2B Mouse Monoclonal Antibody [A5H6]
Catalog# HA600066
ACVR2B Mouse Monoclonal Antibody [A5H6]
-
WB
-
Human
-
Mouse
-
Rat
-
Zebrafish
预测的种属支持售后
概述
产品名称
ACVR2B Mouse Monoclonal Antibody [A5H6]
抗体类型
Mouse Monoclonal Antibody
免疫原
Synthetic peptide within human ACVR2B aa 331-380 / 512.
种属反应性
Human (Predicted: Mouse, Rat, Zebrafish)
预测的种属支持售后
验证应用
WB
分子量
58 kDa
阳性对照
Hela cell lysates.
偶联
unconjugated
克隆号
A5H6
RRID
产品特性
形态
Liquid
浓度
2ug/ul
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG2a
纯化方式
Protein G affinity purified.
应用稀释度
-
WB
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1:500-1:2,000
靶点
功能
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
背景文献
1. Huot JR. et. al. ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia. J Cachexia Sarcopenia Muscle. 2020 Dec
2. Szabó Z. et. al. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. FASEB J. 2020 Aug
亚细胞定位
Cell membrane.
UNIPROT
别名
Activin A receptor type IIB antibody
Activin receptor type 2B antibody
Activin receptor type IIB antibody
Activin receptor type-2B antibody
ActR IIB antibody
ACTR-IIB antibody
ActRIIB antibody
ACVR 2B antibody
ACVR2B antibody
AVR2B_HUMAN antibody
展开图片
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Western blot analysis of ACVR2B on Hela cell lysates. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA600066, 1/500) was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1:20,000 dilution was used for 1 hour at room temperature.
Predicted band size: 58 kDa
Observed band size: 50 kDa
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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