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Anti-ATG12 antibody

兔多抗 | 货号: R1404-1


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价格:RMB   1500
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  • 概述

  • 产品描述 Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy. Autophagy requires the covalent attachment of the protein Atg12 to ATG5 through a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine. Atg12 was found to be involved in apoptosis. This protein promotes apoptosis through an interaction with anti-apoptotic members of the Bcl-2 family.
  • 产品名称 Anti-ATG12 antibody
  • 分子量 15 kDa
  • 种属反应性 Human, Mouse, Rat
  • 验证应用 WB, ICC, IHC-P, FC
  • 抗体类型 兔多抗
  • 免疫原 Synthetic peptide within human ATG12 aa 96-138.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Peptide affinity purified.
  • 亚细胞定位 Cytoplasm
  • 数据链接 O94817
  • 其它名称
    • APG12-like antibody
    • APG12L antibody
    • ATG12 antibody
  • 应用

    WB: 1:500-1:1000
    ICC: 1:200

  • 背景文献

  • 1. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E. J. Biol. Chem. 277:13739-13744(2002)

    2. "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate." Chen D., Fan W., Lu Y., Ding X., Chen S., Zhong Q. Mol. Cell 45:629-641(2012)

    3. "Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy." Otomo C., Metlagel Z., Takaesu G., Otomo T. Nat. Struct. Mol. Biol. 20:59-66(2013)
  • Publishing research using Anti-ATG12 antibody? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols