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Anti-Parkin Recombinant Rabbit Monoclonal Antibody [JF82-09]

重组兔单抗 | 货号: ET1702-60


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价格:RMB   1500
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  • 概述

  • 产品描述 Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2-27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms. Mutations in the Parkin gene are responsible for autosomal recessive juvenile Parkinson's disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution.
  • 产品名称 Anti-Parkin Recombinant Rabbit Monoclonal Antibody [JF82-09]
  • 分子量 52 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,ICC/IF,IHC-P,IP,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within N-terminal human Parkin.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Mitochondrion, mitochondrion outer membrane, endoplasmic reticulum, cytosol, Nucleus, neuron projection, postsynaptic density, presynapse.
  • 数据链接 SwissProt: O60260 Human
    SwissProt: Q9WVS6 Mouse
    SwissProt: Q9JK66 Rat
  • 其它名称
    • AR JP antibody
    • E3 ubiquitin ligase antibody
    • E3 ubiquitin protein ligase parkin antibody
  • 应用

    WB: 1:500-1:1,000
    ICC/IF: 1:50-1:200
    IHC-P: 1:50-1:200
    FC: 1:50-1:100
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Lu Y et al. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells. Int J Mol Med 36:1223-32 (2015).

    2. Seillier M et al. Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18 (2015).
  • Publishing research using Anti-Parkin Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    36338340
    Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals Author: Jiang, H., Chen, F., Song, D., Zhou, X., Ren, L., & Zeng, M. Published: 2022 Application: WB Species: Mouse Journal: Oxid Med Cell Longev. IF: 7.310
  • PMID:
    29515107
    PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway Author: Suzhan Zhang,Weiqi Yan Published: 2018 Application: WB,IF Species: human,mouse Journal: Cell Death Dis. IF: 5.965

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols