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Anti-Transferrin Receptor (CD71) Recombinant Rabbit Monoclonal Antibody [JF0956]

重组兔单抗 | 货号: ET1702-06


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价格:RMB   1500
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  • 概述

  • 产品描述 CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.
  • 产品名称 Anti-Transferrin Receptor (CD71) Recombinant Rabbit Monoclonal Antibody [JF0956]
  • 分子量 85 kDa
  • 种属反应性 Human,Mouse,Rat
  • 验证应用 WB,IHC-P,IP,FC
  • 抗体类型 重组兔单抗
  • 免疫原 Synthetic peptide within Human CD71 aa 22-60 / 760.
  • 偶联 Non-conjugated
  • 性能

  • 形态 Liquid
  • 浓度 1 mg/mL.
  • 存放说明 Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型 IgG
  • 纯化方式 Protein A affinity purified.
  • 亚细胞定位 Cell membrane, Melanosome, Secreted.
  • 数据链接 SwissProt: P02786 Human
    SwissProt: Q62351 Mouse
    SwissProt: Q99376 Rat
  • 其它名称
    • CD 71 antibody
    • CD71 antibody
    • CD71 antigen antibody
  • 应用

    WB: 1:500-1:2,000
    IHC-P: 1:50-1:200
    FC: 1:50-1:100
    IP: Use at an assay dependent concentration.

  • 背景文献

  • 1. Wang Y et al. Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis. Cancer Sci 107:250-7 (2016).

    2. Song J et al. Native low density lipoprotein promotes lipid raft formation in macrophages. Mol Med Rep 13:2087-93 (2016).
  • Publishing research using Anti-Transferrin Receptor (CD71) Recombinant Rabbit Monoclonal Antibody? Please let us know so that we can cite the reference in this datasheet.

  • PMID:
    NA15
    All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis Published: 2022 Application: WB Species: Human Journal: Genes & Diseases IF: 7.103
  • PMID:
    35725567
    Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8 + T cells Author: Liang, J., Shen, Y., Wang, Y., Huang, Y., Wang, J., Zhu, Q., Tong, G., Yu, K., Cao, W., Wang, Q., Li, Y., & Zhao, Y. Published: 2022 Application: WB Species: Mouse Journal: Mol Brain. IF: 4.041

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols