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Epigenetics and Nuclear Signaling - Chromatin Modifying Enzymes

染色质修饰酶是通过转基团或脱基团作用造成染色质蛋白修饰改变的酶家族的总称,是广义染色质结合蛋白的一部分(writers和erasers)。常见的染色质修饰包括组蛋白甲基化,乙酰化,磷酸化和泛素化。染色质修饰酶负责执行或逆转这些修饰基团的转移。比如,组蛋白甲基转移酶催化一个甲基从辅因子s-腺苷甲硫氨酸(SAM)转移到组蛋白尾部的赖氨酸侧链上,使组蛋白发生不同程度的甲基化修饰。

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