Anti-Cleaved-Lamin A (D230) antibody
ER60026
Product Type: Rabbit polyclonal IgG, primary antibodies
Species reactivity: Human, Mouse, Rat
Applications: WB, IHC
Molecular Wt: 28/75 kDa
Description:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Immunogen:
The antiserum was produced against synthesized peptide derived from human Lamin A. AA range:181-230
Positive control:
Colon,Embryonal rhabdomyosarcoma,Epithelium,Kidney,Lung,Ovarian carcinoma,Pancreas,Renal cell carci
Subcellular location:
Nucleus
Database links:
SwissProt: P02545 Human
Recommended Dilutions:
  

WB 1:500-1:2000
IHC 1:100-1:300
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Purity:
Immunogen affinity purified.
Images
Note: All products are “FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE”.